br Conclusions br An enriched diet with
An enriched diet with selenized chickpea sprouts containing su-pranutritional levels of selenium (2.29 µg/g diet) with or without iso-flavonoids, significantly decreased the tumor growth of colon cancer Norfloxacin xenografted in immune-suppressed mice. High dietary selenium intake enhanced the antioxidant activity of glutathione peroxidase and thioredoxin reductase and therefore decreased the cellular redox state. The prevention of lipid oxidation under hypoxic conditions negatively affected tumor growth. Se-enriched chickpea sprouts consumption could contribute to the reduction of cancer cells proliferation.
6. Ethics statement
The authors declare that the present investigation was carried out in compliance with the laws and regulations for its publication.
D. Guardado-Félix et al.
7. Competing interests
The authors do not have any conflicts of interest to declare.
This research was supported by the NutriOmics Research Chair Funds from Tecnológico de Monterrey. The scholarship of Daniela Guardado Félix (CVU-231081) was provided by Consejo Nacional de Ciencia y Tecnología (CONACYT) and the Universidad Autónoma de Sinaloa. The authors would also like to thank Laura Acevedo and Felipe López for their invaluable support of this research.
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Fig. 6. Proposed mechanisms for chemopre-ventive effect of sprouted chickpea diets containing different amounts of selenium and isoflavonoids in immune suppressed male mice xenografted with HT-29 RFP cells. (A) Activation of the apoptotic intrinsic pathway.
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