Archives

  • 2022-06
  • 2022-05
  • 2022-04
  • 2021-03
  • 2020-08
  • 2020-07
  • 2020-03
  • 2019-11
  • 2019-10
  • 2019-09
  • 2019-08
  • 2019-07
  • br Conclusions br An enriched diet with

    2022-04-26


    5. Conclusions
    An enriched diet with selenized chickpea sprouts containing su-pranutritional levels of selenium (2.29 µg/g diet) with or without iso-flavonoids, significantly decreased the tumor growth of colon cancer Norfloxacin xenografted in immune-suppressed mice. High dietary selenium intake enhanced the antioxidant activity of glutathione peroxidase and thioredoxin reductase and therefore decreased the cellular redox state. The prevention of lipid oxidation under hypoxic conditions negatively affected tumor growth. Se-enriched chickpea sprouts consumption could contribute to the reduction of cancer cells proliferation.
    6. Ethics statement
    The authors declare that the present investigation was carried out in compliance with the laws and regulations for its publication.
    D. Guardado-Félix et al.
    7. Competing interests
    The authors do not have any conflicts of interest to declare.
    Acknowledgements
    This research was supported by the NutriOmics Research Chair Funds from Tecnológico de Monterrey. The scholarship of Daniela Guardado Félix (CVU-231081) was provided by Consejo Nacional de Ciencia y Tecnología (CONACYT) and the Universidad Autónoma de Sinaloa. The authors would also like to thank Laura Acevedo and Felipe López for their invaluable support of this research.
    References
    Beloribi-Djefaflia, S., Vasseur, S., & Guillaumond, F. (2016). Lipid metabolic repro-gramming in cancer cells. Oncogenesis, 5e189. Bhattacharya, A., Turowski, S. G., San Martin, I. D., Rajput, A., Rustum, Y. M., Hoffman, R. M., & Seshadri, M. (2011). Magnetic resonance and fluorescence-protein imaging of the anti-angiogenic and anti-tumor efficacy of selenium in an arthotopic model of human colon cancer. Anticancer Research, 31, 387–394.
    foods for special medical purposes. Molecular Nutrition and Food Research, 51, 1305–1312.
    Fernandes, A. P., & Gandin, G. (2015). Selenium compounds as therapeutic agents in cancer. Biochimica et Biophysica. Acta (BBA) - General Subjects, 1850, 1642–1660. GLOBOCAN (2012). Graph production: Global cancer observatory. International Agency for Research on Cancer. < http://globocan.iarc.fr/Default.aspx > (accessed 15 January 2018). Guo, C. H., Hsia, S., Hsiunge, D. Y., & Chend, P. C. (2015). Supplementation with Selenium yeast on the prooxidant-antioxidant activities and anti-tumor effects in breast tumor xenograft-bearing mice. The Journal of Nutritional Biochemistry, 26,  Journal of Functional Foods 53 (2019) 76–84
    Fig. 6. Proposed mechanisms for chemopre-ventive effect of sprouted chickpea diets containing different amounts of selenium and isoflavonoids in immune suppressed male mice xenografted with HT-29 RFP cells. (A) Activation of the apoptotic intrinsic pathway.
    (B) Activation of the apoptotic extrinsic pathway. (C) Antioxidant protection of lipids through glutathione peroxidase. GC: Germinated control; GSe1: High content of selenium and isoflavonoids; GSe2: High con-tent of selenium without presence of iso-flavonoids. ROOH: Lipid hydroperoxide; GSH: Reduced glutathione; GSSG: Glutathione dis-ulfide: H2O: water.
    Guardado-Félix, D., Serna-Saldivar, S. O., Cuevas-Rodríguez, E. O., Jacobo-Velázquez, D. A., & Gutiérrez-Uribe, J. A. (2017). Effect of sodium selenite on isoflavonoid contents and antioxidant capacity of chickpea (Cicer arietinum L.) sprouts. Food Chemistry, 226, 69–74.
    colorectal oncogenesis by selenium-enriched milk proteins: Apoptosis and K-ras mutations. Cancer Research, 68, 4936–4944.
    techniques used for the assay of isoflavones from soybean. Food Chemistry, 105, 325–333.
    Maseko, T., Howell, K., Dunshea, F. R., & Ng, K. (2014). Selenium-enriched Agaricus bisporus increases expression and activity of glutathione peroxidase-1 and expression of glutathione peroxidase-2 in rat colon. Food Chemistry, 146, 327–333.
    D. Guardado-Félix et al.
    (2013). In vitro bioavailability of total selenium species from seafood. Food Chemistry,
    Nandhakumar, E., Purushothaman, A., & Sachdanandam, P. (2014). Protective effect of Shemamruthaa on lipids anomalies in 7, 12-dimethylbenz [a] anthracene (DMBA)-induced mammary carcinoma-bearing rats. Medicinal Chemistry Research, 23, 3491–3502.
    Yoshida, M., Okada, T., Namikawa, Y., Matsuzaki, Y., Nishiyama, T., & Fukunaga, K. (2007). Evaluation of nutritional availability and anti-tumor activity of selenium contained in selenium-enriched Kaiware radish sprouts. Bioscience, Biotechnology, and Biochemistry, 71, 2198–2205.
    Yu, Y., Zhang, F., Lu, D., & Zhang, H. (2014). Selenium bioavailability from shrimps (Penaeus vannamei Boone) and its effect on the metabolism of phospholipid and cholesterol ester. Journal of Functional Foods, 6, 186–195.