• Note that global PC incidence and mortality have been

  2019-08-11

  

  Note that global PC incidence and mortality have been reported to correlate directly with country-specific levels of socioeconomic development [17] which seems in K 252a to the higher PC incidence we found in eastern Europe compared to the rest of Europe. We found that survival for PC and BTC impr

• Age has been the main

  2019-08-11

  

  Age has been the main demographic factor used for targeting Australian screening programs [1]. The National Breast Screening Program actively invites women aged from 50 to 74 years for biennial screening. The National Cervical Screening Program has been using HPV (human papillomavirus) testing since

• br Competing interests declaration br Introduction N acetylc

  2019-07-30

  

  Competing interests declaration Introduction N-acetylcysteine (NAC) is widely used in a variety of diseases and presents a good safety profile. Some of its therapeutic effects are supposed to be secondary to its antioxidant effects. NAC is readily hydrolyzed to cysteine, a precursor of glutath

• br Conflict of interest br

  2019-07-30

  

  Conflict of interest Transparency document Introduction Multiple Sclerosis (MS) is an autoimmune disease characterized by complex genetic features and pathology that translate into clinical heterogeneity [1]. During multiple sclerosis, axonal destruction and neuronal loss occur early, and t

• Doxycycline Dc is of special interest because

  2019-07-30

  

  Doxycycline (Dc) is of special interest because it is the most potent MMP inhibitor of the tetracycline-class antibiotics. Its mechanism of action involves Zn chelation, a property distinct from the antibacterial action [22]. Many studies have demonstrated the beneficial use of tetracycline for seve

• br Disclosure statement br Transparency document br Introduc

  2019-07-24

  

  Disclosure statement Transparency document Introduction Peroxisome proliferator-activated receptors (PPARs) are ligand-dependent transcription factors that regulate lipid homeostasis [1] and PPAR isoforms regulate lipolysis, adipogenesis, and metabolism [2]. Interestingly, posttranslational

• Thonzonium Bromide The observation that PNPLA in

  2019-07-08

  

  The observation that PNPLA3, in addition to its potential role as LPAAT and TAG lipase, may also act as RE hydrolase was made after the generation of the knockout, transgenic and knock in mouse models. Thus, in any of these mouse models the mobilization of RE stores has not been addressed. Yet, two

• Our adenine treated animals exhibited increased BUN aprox

  2019-07-08

  

  Our adenine-treated animals exhibited increased BUN (aprox 5-fold), creatinine (aprox 2-fold), and urine volume (aprox 6-fold). These changes are characteristic of patients with predominant tubule-interstitial damage in early-middle stages. Other authors have made similar approaches by studying anim

• The following are the supplementary data related to

  2019-07-08

  

  The following are the supplementary data related to this article. Conflicts of interest Transparency document Introduction Heart failure (HF) is a debilitating disease with high rates of mortality. The pathogenesis underlying HF is complex but is mostly related to cardiac remodeling caused

• Loss of ABCA function is not only due to

  2019-07-06

  

  Loss of ABCA1 function is not only due to its mutations, which is rare, and the use of CsA, which is gradually replaced by other immunosuppressive drugs, but is also caused by reduced expression in aging macrophages [29]. The present study for the first time shows that the expression of ABCA1 in the

• Overexpression of GCP has been linked to improved

  2019-07-06

  

  Overexpression of GCP-2 has been linked to improved LV remodeling by increasing pro-angiogenic and anti-apoptotic gene expression within the infarct [36]. Less is known about the role of lymphotactin (Xcl1) during the cardiac remodeling processes, in part due to conflicting results. In a rat model o

• Genetic variants in noncoding RNAs

  2019-07-05

  

  Genetic variants in noncoding RNAs have the potential to differentially influence aging processes and lifespan. The lncRNA ANRIL, was implicated in longevity in a GWAS [96]. Understanding genetic variants in the noncoding genome is a current challenge. Constrained regions in the noncoding genome ass

• br Transparency document br Acknowledgements The authors

  2019-07-05

  

  Transparency document Acknowledgements The authors gratefully acknowledge the National Institute on Minority Health and Health Disparities (G12MD007591). Introduction Alzheimer's disease (AD) is the leading cause of dementia in the elderly population, affecting approximately 40 million peo

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