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The following are the supplementary data related to
2019-07-08
The following are the supplementary data related to this article. Conflicts of interest Transparency document Introduction Heart failure (HF) is a debilitating disease with high rates of mortality. The pathogenesis underlying HF is complex but is mostly related to cardiac remodeling caused
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Loss of ABCA function is not only due to
2019-07-06
Loss of ABCA1 function is not only due to its mutations, which is rare, and the use of CsA, which is gradually replaced by other immunosuppressive drugs, but is also caused by reduced expression in aging macrophages [29]. The present study for the first time shows that the expression of ABCA1 in the
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Overexpression of GCP has been linked to improved
2019-07-06
Overexpression of GCP-2 has been linked to improved LV remodeling by increasing pro-angiogenic and anti-apoptotic gene expression within the infarct [36]. Less is known about the role of lymphotactin (Xcl1) during the cardiac remodeling processes, in part due to conflicting results. In a rat model o
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Genetic variants in noncoding RNAs
2019-07-05
Genetic variants in noncoding RNAs have the potential to differentially influence aging processes and lifespan. The lncRNA ANRIL, was implicated in longevity in a GWAS [96]. Understanding genetic variants in the noncoding genome is a current challenge. Constrained regions in the noncoding genome ass
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br Transparency document br Acknowledgements The authors
2019-07-05
Transparency document Acknowledgements The authors gratefully acknowledge the National Institute on Minority Health and Health Disparities (G12MD007591). Introduction Alzheimer's disease (AD) is the leading cause of dementia in the elderly population, affecting approximately 40 million peo
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